Boston, Massachusetts – In an article published in the New England Journal of Medicine, medical researchers have achieved a possible breakthrough in the diagnosis of the chronic traumatic encephalopathy (CTE), a neurodegenerative illness, in living patients. While the medical researchers are cautious about its applicability, their achievement may well represent the revolutionary first step in a task that has eluded the scientific and medical communities since CTE was first discovered.
Several institutions including Mayo Clinic Arizona and Boston University were involved in the research. By using an experimental positron emission tomography (PET) scan, the researchers detected abnormal tau protein deposits in the brains of living former National Football League (NFL) players. The researchers also determined that the NFL subjects have higher levels of tau protein than non-football players of similar age.
Up until this research, doctors and other medical professionals were unable to detect abnormal tau deposits in living subjects. Instead, these deposits can only be examined in the brain after an individual’s death.
The PET scan is an imaging test that allows medical professionals to check for diseases in the body. The technology uses a special dye with radioactive tracers that can be swallowed, injected into a vein, or inhaled depending on the body part being examined.
The dense buildup of tau proteins in the body is associated with the wide range of behavioral and cognitive symptoms in people affected by CTE. The early symptoms include issues with impulse control, depression, and aggression, as well as decreased executive functioning, mild memory loss, and paranoia. These typically appear during the affected person’s 20s or early 30s.
The mood and behavioral symptoms are likely to appear first followed by the cognitive symptoms, which usually appear during the patient’s 40s or 50s. Every patient has a specific response to the disease, too.
While some patients will experience the behavioral and mood symptoms only, some patients will also experience both clusters of symptoms. Some patients may also have worsening symptoms over time regardless of whether they have suffered additional head impacts or not. Some patients may also have stable symptoms over several years before these become worse.
Former athletes particularly college and professional football players in the NFL have been plagued by these symptoms. The possible breakthrough in diagnosis in living patients can mean more effective CTE treatments may well happen in the near future.
While the researchers observed higher tau protein levels among subjects who have played football for years, they didn’t find a relationship between the subjects’ moods, behaviors, and cognitive test performance and these levels.
The researchers are quick to point out that their work isn’t a diagnostic tool. But it’s an advancement in terms of more effective and efficient individual assessments.
According to Chris Nowinski, the co-founder and chief executive officer of the Concussion Legacy Foundation, “It’s an exciting positive step toward a diagnosis in the living.” He further said that it’s important to tell others that while it may not yet be ready for patients, people who are at risk for CTE are excited about it and the progress being made by top scientists.
The research involved 26 former NFL players and 31 men of similar ages (from 40 to 69 years old). The former exhibited symptoms consistent with CTE while the latter didn’t have the symptoms or didn’t have a history of traumatic brain injuries.
The researchers used two types of markers. In one scan, they injected a flortaucipir marker into the subjects. The marker bonds with tau proteins and makes them visible under the scan’s cameras.
In the other scan, they administered an amyloid marker to the subjects. The marker makes the plaque buildup associated with another degenerative disease, Alzheimer’s disease, visible.
The researchers used both markers to suggest that the former football players’ symptoms weren’t likely caused by Alzheimer’s disease.
According to Dr. Robert A. Stern, the director of clinical research at Boston University’s CTE Center and the study’s author, “In this case, the tau PET scan showed elevations of taus in three primary areas of the brain compared to the control group, and those areas are consistent with where we’d expect to find abnormal tau in the postmortem evaluations for CTE.”
The research is among the latest study designed toward making an effective diagnostic CTE tool for living at-risk patients. Blood exams and MRI scans, among other technologies, have also been used for this purpose.
Furthermore, Dr. Stern emphasized that the finding is important but it isn’t the answer. Researchers are still a long way from their goal of finding a truly effective and efficient diagnostic tool.
Boston University’s CTE Center has plans of observing subjects longitudinally (i.e., across time) using data from an ongoing National Institutes of Health-funded study. The researchers will record the subjects’ symptoms and analyze their brains through the multiple images generated.
Dr. Harrison Martland first described CTE when he described a group of boxers with so-called punch drunk syndrome. In the ensuing years, several researchers added to the initial data but there were less than 50 cases were confirmed. In 2005, Bennet Omalu, a pathologist, published his findings on CTE in Mike Webster, a former NFL player. Since then, various organizations and institutions have been dedicated to finding effective diagnostic tools, causes and treatment for CTE.
에볼루션접속 먹튀검증 안전노리터 go
I Was Eagerly Looking For Content Like This, Right To The Point And Detailed As Well Accordingly Depending Upon The Matter/Topic. You Have Managed This Greatly For Sure. Bape Hoodie
This is a really decent site post. Not very numerous individuals would really, the way you simply did. I am truly inspired that there is such a great amount of data about this subject have been revealed and you’ve put worth a valiant effort with so much class. Squid Game Outfits
Fashion is the thing that you make it – The primary thing you need to comprehend about fashion is that it is just what you make it, that’s it. Chris Evans Knives out Sweater
I am aware that a large portion of you absolutely adore wearing denim jackets. Without a doubt, I am one of you. Stranger Things Nancy Wheeler Jacket I adore it since it goes well with a wide variety of clothing and fashions and is very adaptable.
you are doing a very great job, the articles are very informative, keep posting, and keep it up.
Everyone looks for the best gear that offers the most comfort all day long. As a result, Mens Green Baseball Varsity Jacket is presented by Real Leather Jackets (RLeatherJackets). It is a beautiful coat with an attractive appearance that shields your body from chilly winds and gives you a captivating look that will make you the centre of attention at any occasion. Therefore, if you consider yourself stylish, you must buy this green baseball jacket.
You can now purchase one of the greatest and most wanted leather jackets from The Jacketars and have it delivered right to your door. We have earned our customers’ trust by giving the best quality service over the last ten years. The Jacketars are renowned for their wide variety of leather clothing. Additionally, both men’s and women’s fur trench coats and skinny fit Blazers are available in our inventory and also yellowstone hoodie.
The Duttons are a landmark in Yellowstone. led by John Dutton, owner of the oldest continuously operating ranch in the US. Additionally, residents who live on its borders have constantly threatened it.
I love your blog entry about Moving Day in Boston. It was exceptionally complete, and I value that you carefully described the why’s, the manner by which’s, and what’s of Moving and the city of Boston. Certainly an extraordinary read!
Denny carmichael suiting blazer
It’s really great. Thank you for providing a quality article. There is something you might be interested in. Do you know baccaratcommunity ? If you have more questions, please come to my site and check it out!
You there, this is really good post here. Thanks for taking the time to post such valuable information.
You’re so cool! I dont suppose I’ve read anything this way prior. So nice to find somebody with a few original applications for grants on this subject. realy we appreciate you beginning descendants 2 jay leather vest this up. this website is one area that is required over the internet, somebody if we do originality. useful purpose of bringing something new to the net!
your blog is great thanks for sharing
Amazing blog it is very helpful and informative cole hauser jacket content good work. Keep it up. excellent post it is full of knowledge and inspiring content and good work. Keep it up.
It is very informative information regarding medical neurological illness. thank you for sharing it.
I have been looking for articles on these topics for a long time. totosite I don’t know how grateful you are for posting on this topic. Thank you for the numerous articles on this site, I will subscribe to those links in my bookmarks and visit them often. Have a nice day
You there, this is an excellent post. I appreciate you taking the time to publish this important information. Iron Man Costume Suit wonderful blog, thanks for sharing
This weblog web page is extraordinary!black yellowstone jacket Please share extra writing like it. It become absolutely really worth the time.
It’s not all about how you work hard but it’s about how you manage your time, resources, mind to work together for a better output 제이나인 먹튀 검증 소 https://j9korea.com/
Very interesting points you have noted , thanks for putting up. nick saban leather jacket
돈을 쓰지 않고 게임을 찾고 계십니까? 우리의 플레이 바카라 무료 내기. 이것은 웹에서 무료로 바카라를 플레이할 수 있는 최고의 장소입니다.
From some point on, I am preparing to build my site while browsing various sites. It is now somewhat completed. If you are interested, please come to play with casinocommunity !!
I once again find myself personally spending way too much time both reading and leaving comments
Just the information I am finding everywhere.
This is really an amazing article.
I’m so glad I stumbled upon this offer.
I’ll definitely be placing an order. Peaky Blinder Costume
Thanks for sharing. It is an important factor that if we want a healthy life, we should take natural and healthy food. You can also visit our website where you can buy the new style leather jacket.
First of all, thank you for your post. bitcoincasino Your posts are neatly organized with the information I want, so there are plenty of resources to reference. I bookmark this site and will find your posts frequently in the future. Thanks again ^^
I’ve been searching for hours on this topic and finally found your post. slotsite, I have read your post and I am very impressed. We prefer your opinion and will visit this site frequently to refer to your opinion. When would you like to visit my site?
But I must say that it is debate that change things. Anyway, very good article, thanks for the share….
It is imperative that we read blog post very carefully.
However, I must state that it is discussion that causes things to change. Anyway, great article, thanks for sharing….
According to the recent article on Boston Leader, a glimmer of hope has emerged for living patients suffering from chronic traumatic encephalopathy (CTE), as new diagnostic testing has been announced that could potentially detect the condition in its early stages.
The article published on Bostonleader.com about a breakthrough development in diagnostic testing for chronic traumatic encephalopathy (CTE) has garnered a significant response and one reader, in particular, left an interesting comment (#20344) that presents further insight into the potential impact of this new discovery.
This exciting development could pave the way for earlier diagnosis and intervention, as well as improved understanding of how CTE develops and progresses over time.
Boston based researchers have recently announced a promising development in the field of neurological research. Specifically focused on the diagnosis of Chronic Traumatic Encephalopathy (CTE) in living patients, this new tool offers hope for detection and early intervention in those individuals who have suffered repeated blows to the head.
The new diagnostic test seeks to measure the level of Tau protein in the brain, which is a key indicator of CTE, through the use of a neuroimaging agent that can be seen on a PET scan and will facilitate early detection of the disease in living patients. The announcement of this breakthrough scientific development brings much-needed hope for the future.